Deadly brain cancer stopped with new compound – Study
One of the reasons why Glioblastoma is so deadly is that they arise from a type of brain cell called Astrocyte
Furthermore, the tumours, it says, grow rapidly because Astrocytes provide support to neurons and control the amount of blood that reaches them when tumours form, they have access to a large number of blood vessels, helping cancerous cells to grow and spread very quickly.
Glioblastomas, it adds, are difficult to treat because there is a high rate of recurrence and this is partly due to a subpopulation of cells contained in the tumor called Glioma Stem Cells – a type of self-regenerating cancer stem cell that controls the growth of tumors.
A Research Assistant Professor of Pathology at the Northwestern University Feinberg School of Medicine in Chicago, IL, Subhas Mukherjee, and his colleagues have been studying the behaviour of these cells for a few years.
Building on this previous research, Mukherjee and his team have now found that these cells contain high levels of an enzyme called CDK5.
By blocking this enzyme, the researchers show in their new study that it stops Glioblastomas from growing and inhibits the self-regenerating capabilities of GSCs.